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Until recently, astrocytic Broussard LA sexy women production has been demonstrated mainly as a slow reaction to detrimental events through the activity of an inducible NOS isoform iNOS.
Prior data from Fwb real friends with benefits in Norway laboratory described for the first time rapid astrocytic NO release in brains of healthy animals. Evaluation of the mutants' behavior in several behavioral tests revealed increased anxiety-like responses, with no differences in motor activity Buskila et al.
To further characterize the behavioral phenotype, we compared the performance of mutant mice to their controls in their response to stress.
Seven days after exposure to predator scent Attractive swf seeking older man PSSmutants exhibited higher anxiety-like behavior in the elevated-plus maze and stronger acoustic startle response. No such differences between groups were observed without the stress exposure. Plasma corticosterone levels were ificantly higher in mutant mice following PSS, further demonstrating their heightened sensitivity to stress.
Interestingly, mutant mice performed better on the Morris water maze MWM under control conditions. The possibility of improved cognition in these mice was not supported as these mutants failed to show improved performance in the object recognition test.
The MWM are probably due to enhanced motivation under water maze stress conditions in mutant mice compared to controls. Taken together, our confirm higher susceptibility to stressful conditions in an astrocytic NOS mouse mutant.
Supported by a grant from the Israel Science Foundation to Y.
Published online Jan 1.